Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 5th Edition, provides a unique, integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps both undergraduate and graduate students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Hundreds of clear, concise illustrations highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms, and dozens of popular and practical drug summary tables offer quick access to essential information. All chapters have been comprehensively updated, including recently discovered mechanisms and recently approved drugs. Content updates, new chapters, new figures, and new cases added to key areas such as endophenotypes as drug targets, immunotherapy, protein-based therapeutics, oligonucleotide-based therapies, and gene therapy and gene editing. Dr. David Golan's pathophysiologic approach, pioneered at Harvard, mirrors critical thinking and is ideal for integrated, systems-based courses.