Almost half of adults in the UK suffer from chronic pain. Yet this is often unrelated to any physical injury. So why does it still hurt? Research over the last few decades shows that many of us are victims of a devilish trick of the nervous system: our brains prolong pain long after our bodies have healed from injury. This leads to hundreds of billions of pounds being spent each year on treatments that sometimes do nothing and sometimes make matters worse. Paul Biegler, a science journalist and former doctor who has been on his own pain journey, investigates the true source of chronic pain — our brain’s so-called neuroplasticity — and emerging therapies that can rewire the brain and end suffering. As he knows only too well, this doesn’t mean pain is all in a person’s head. Pain is real, but its meaning is often misunderstood. Through conversations with scientists, doctors, and people who have overcome chronic pain, Biegler shines a light on the rigorous new studies — and emotional