Something dark is lurking in the Louisiana bayou: a methodical killer with a penchant for medical experimentation is hard at work completing his most harrowing crime yet, taunting the authorities who desperately try to catch up. But forensic pathologist Dr. Wren Muller is the best there is. Armed with an encyclopedic knowledge of historical crimes, and years of experience working in the Medical Examiner's office, she's never encountered a case she couldn't solve. Until now. Case after case is piling up on Wren's examination table, and soon she is sucked into an all-consuming cat-and-mouse chase with a brutal murderer getting more brazen by the day.