Informatics of Domination is an experimental collection addressing formations of power that manifest through technical systems and white capitalist patriarchy in the twenty-first century. The volume takes its name from a chart in Donna J. Haraway’s canonical 1985 essay “A Manifesto for Cyborgs.” Haraway theorizes the informatics of domination as a feminist, diagrammatic concept for situating power and a world system from which the figure of the cyborg emerges. Informatics of Domination builds on Haraway’s chart as an open structure for thought, inviting fifty scholars, artists, and creative writers to unfold new perspectives. Their writings take on a variety of forms, such as essays on artificial intelligence, disability and protest, and transpacific imaginaries; conversations with an AI trained on Black oral history; a three-dimensional response to Mexico-US border tensions; hand-drawn images on queer autotheory; ecological fictions about gut microbiomes and wet markets; and more.