A wide-ranging and dramatic account of the Antonine plague, the mysterious disease that struck the Roman Empire at its pinnacle In the middle of the second century AD, Rome was at its prosperous and powerful apex. The emperor Marcus Aurelius reigned over a vast territory that stretched from Britain to Egypt. The Roman-made peace, or Pax Romana, seemed to be permanent. Then, apparently out of nowhere, a sudden sickness struck the legions and laid waste to cities, including Rome itself. This fast-spreading disease, now known as the Antonine plague, may have been history’s first pandemic. Soon after its arrival, the Empire began its downward trajectory toward decline and fall. In Pox Romana, historian Colin Elliott offers a comprehensive, wide-ranging account of this pivotal moment in Roman history. Did a single disease—its origins and diagnosis still a mystery—bring Rome to its knees? Carefully examining all the available evidence, Elliott shows that Rome’s problems were more insidious.