This work has been thoughtfully designed so that it serves equally well as a reference for the practitioner and as a self-contained textbook for the advanced student.* Rewritten to maintain clarity and brevity while expanding the coverage of previous editions.* Changes to design-related topics include increased discussion of mixed models and random effects, greater emphasis on regression and data screening, and more use of graphs throughout.* Includes both graded and challenging exercises.* Liberal computer discussions now supplemented with SAS and SPSS.