Medical imaging is increasingly at the base of many breakthroughs in biomedical sciences, becoming a fundamental enabling technology of biomedical scientific progress. Medical Image Analysis presents practical knowledge on medical image computing and analysis and is written by top educators and experts in the field. This text is a modern, practical, broad, and self-contained reference that conveys a mix of essential methodological concepts within different medical domains, reflecting the nature of the discipline today, making it suitable as a course text and a self-learning resource.An authoritative presentation of key concepts and methods from experts in the fieldSections clearly explaining key methodological principles within relevant medical applicationsSelf-contained chapters enable the text to be used on courses with differing structuresA representative selection of modern topics and techniques in medical image computingFocus on medical image computing as an enabling technology to tackle unmet clinical needsPresentation of traditional and machine learning approaches to medical image computing